![]() GI disorders: Inflammatory bowel conditions such as Crohn’s disease and ulcerative colitis can affect the lining of the large intestine, leading to abdominal discomfort. Swallowing too much air-called aerophagia-during times of eating, chewing, mouth breathing, and hyperventilation can also lead to abdominal discomfort due to splenic flexure syndrome. Undigested food in the digestive tract commonly produces excessive amounts of gas. This may be caused by fatty foods and gas production leading to abdominal distention. Relief of gas accumulation can be achieved by simply passing gas, but unfortunately, those with splenic flexure syndrome have difficulty doing so.Ībdominal distention: This can occur when too much space accumulates in the gastric area, leading to feelings of discomfort. The trapped air pushes on the inner lining of the gastric mucosa, putting pressure on the surrounding structures, leading to pain and discomfort. Gas accumulation: This is thought to be the most common cause of splenic flexure syndrome and it occurs due to trapped air in the gastrointestinal tract. The tumors usually develop during early or middle adulthood but may develop at any age they are. read more, and brain Overview of Intracranial Tumors Intracranial tumors may involve the brain or other structures (eg, cranial nerves, meninges). Small-bowel cancer accounts for an estimated 11,110 cases and about 1,700 deaths in the US annually ( 1). read more, biliary tree, gallbladder, small bowel Small-Bowel Tumors Small-bowel tumors account for 1 to 5% of gastrointestinal tumors. Symptoms include weight loss, abdominal pain, and jaundice. ![]() read more, urinary tract, pancreas Pancreatic Cancer Pancreatic cancer, primarily ductal adenocarcinoma, accounts for an estimated 57,600 cases and 47,050 deaths in the US annually ( 1). ![]() Symptoms include early satiety, obstruction, and bleeding but tend to occur late in the. Patients also have an elevated risk of other cancers, including of the stomach Stomach Cancer Etiology of stomach cancer is multifactorial, but Helicobacter pylori plays a significant role. read more (39% risk of endometrial and 9% risk of ovarian by age 70). The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. read more and ovarian tumors Ovarian, Fallopian Tube, and Peritoneal Cancer Ovarian cancer is often fatal because it is usually advanced when diagnosed. Typically, it manifests as postmenopausal uterine bleeding. Other common associated cancers include endometrial tumors Endometrial Cancer Endometrial cancer is usually endometrioid adenocarcinoma. The low-grade skin cancer, keratoacanthoma Keratoacanthoma Keratoacanthomas are round, firm, usually flesh-colored nodules with sharply sloping borders and a characteristic central crater containing keratinous material they usually resolve spontaneously. Nonmalignant disorders include café-au-lait spots and sebaceous gland tumors. However, similar to familial adenomatous polyposis, numerous extracolonic manifestations occur. read more, the other main hereditary form of CRC. Patients are usually asymptomatic but may. The precursor lesion is usually a single colonic adenoma, unlike the multiple adenomas present in patients with familial adenomatous polyposis Familial Adenomatous Polyposis Familial adenomatous polyposis is a hereditary disorder causing numerous colonic polyps and frequently resulting in colon carcinoma, often by age 40. Compared to sporadic forms of colon cancer, Lynch syndrome occurs at a younger age (mid 40s), and the lesion is more likely to be proximal to the splenic flexure. Screening using one of several methods is recommended for appropriate populations. ![]() Symptoms include blood in the stool and change in bowel habits. ![]() Lynch syndrome is an autosomal dominant disorder in which patients with one of several known genetic mutations that impair DNA mismatch repair have a 70 to 80% lifetime risk of developing colorectal cancer Colorectal Cancer Colorectal cancer is extremely common. ![]()
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